Conference Summary

This FASEB Science Research Conference (SRC) is focused on the role of NAD+ in the basic biology of aging, metabolism, and cancer, including chemistry, biochemistry, physiology, and omics, as well as evidence-based interventions to improve human health.

NAD+-dependent enzymes, ion channels regulated by NAD+-derivatives, or other proteins that bind NAD+ or its derivatives, play essential roles in all aspects of human biology. This includes core metabolism, gene regulation, epigenetic silencing, DNA repair and genome maintenance, calcium signaling, resistance to reactive oxygen species, enzyme regulation in all cellular compartments, mitosis, cell death, stress responses, inflammation, and hormonal signaling.

Many of these processes are important regulators of the aging process. A variety of NAD+ based therapeutic and nutritional interventions are currently being developed to promote healthy aging. As such, NAD+ biology is an important area for research - one that has great potential to impact human health in areas such as aging, metabolic disease, and cancer.

This virtual conference will bring together basic scientists interested in metabolism and metabolic signaling. This meeting provides a unique venue for cross-disciplinary interactions among NAD+ biologists from diverse areas who use a wide variety of approaches and model systems.

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W. Lee Kraus, PhD
Professor, Obstetrics & Gynecology and Pharmacology and Director, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, USA

Andreas H. Guse, PhD
Professor and Department Head, Biochemistry and Molecular Cell Biology, University Medical Center, Hamburg-Eppendorf, Germany

Raul Mostoslavsky, MD, PhD
Scientific Co-Director, Massachusetts General Hospital Cancer Center, Boston, and the Laurel Schwartz Professor of Oncology (Medicine), Harvard Medical School, and Associate Member, The Broad Institute, Cambridge, MA, USA

Vera Gorbunova, PhD
Professor of Biology, University of Rochester and the Rochester Aging Research Center, NY, USA


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