 |
Agenda
Please note that this is a tentative agenda. Most talks will be pre-recorded with live question/answer periods. All times presented are in Eastern Daylight Time (EDT).
Wednesday June 30, 2021
| Time – EDT Time | Event – The Protein Lipidation Conference |
| 08:30 am – 08:45 am | Conference Opens - Welcome Day I Organizers: James Hougland, Paul Jenkins, and Mei Wang |
| 08:45 am – 09:15 am | Keynote Lecture: Dr. Martin Bergö (Karolinska Institute) Defining the Efficacy of Targeting ICMT in Cancer and Progeria Moderator: James Hougland |
| 09:15 am – 09:30 am | Live Q&A with the Keynote Speaker Moderator: James Hougland |
| 09:30 am – 09:45 am | Break |
| 9:45 am – 12:00 pm | Session 1: DRUG DISCOVERY AND CHEMICAL TOOLS FOR STUDYING PROTEIN LIPIDATION Session Chair: Mei Wang |
| 09:45 am – 10:05 am | Ed Tate, Drugging protein lipidation |
| 10:05 am – 10:25 am | Dolores Di Vizio, High-throughput palmitoyl-proteomics profiling of prostate cancer-derived extracellular vesicles |
| 10:25 am – 10:40 am | Short Talk 1: Saara-Anne Azizi, An acrylamide-based inhibitor of DHHC family proteins to probe ERK1/2 acylation |
| 10:40 am – 10:55 am | Live Q&A Panel Discussion |
| 10:55 am - 11:15 am | Luc Berthiaume, N-myristoyltransferase inhibitors for lymphoma and leukemia: our journey to clinical trials |
| 11:15 am – 11:30 am | Short Talk 2: Javier Valdez-Taubas, A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors |
| 11:30 am – 11:45 am | Short Talk 3: Cory (Tony) Ocasio, ZDHHC chemical genetics reveals novel S-acylation-linked biology |
| 11:45 am – 12:00 pm | Live Q&A Panel Discussion |
| 12:00 pm – 12:15 pm | Break |
| 12:15 pm – 1:15 pm | Meet the Experts Greg Fairn; Carol Williams; Anirban Banerjee; Carmela Giglione; Liz Conibear Moderator: James Hougland |
| 1:15 pm - 3:30 pm | Session 2: PROTEIN LIPIDATION IN IMMUNOLOGY, SIGNALING, AND DISEASE Session Chair: Paul Jenkins |
| 1:15 pm – 1:35 pm | Donghai Wang, Role of Protein Geranylgeranylation in Anti-viral Innate Immune Response |
| 1:35 pm – 1:55 pm | Shernaz Bamji, Palmitoylating Enzymes in Brain Development and Disease |
| 1:55 pm – 2:10 pm | Short Talk 4: Julie Gupta, Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage gated sodium channel Nav1.2 in neurons |
| 2:10 pm – 2:25 pm | Live Q&A Panel Discussion |
| 2:25 pm – 2:45 pm | Rejji Kuruvilla, Compartmentalized protein synthesis and lipidation in axon growth |
| 2:45 pm – 3:00 pm | Short Talk 5: Caglar Gok, Insulin mediated palmitoylation in NCX1 function |
| 3:00 pm – 3:15 pm | Short Talk 6: Rocio Hollman, The palmitoylating enzyme, zDHHC9, in intellectual disability |
| 3:15 pm – 3:30 pm | Live Q&A Panel Discussion |
| 3:35 pm – 5:00 pm | Poster Session 1 |
| 5:00 pm – 5:15 pm | Conclusion - End of Day I |
Thursday July 1, 2021
| Time - EDT | Event – The Protein Lipidation Conference |
| 08:30 am – 08:45 am | Day 2 Welcome Address |
| 08:45 am – 09:15 am | Keynote Lecture: Dr. Gisou van der Goot (EPFL) Palmitoylation of SARS-CoV2 Moderator: James Hougland |
| 09:15 am – 09:30 am | Live Q&A with the Keynote Speaker Moderator: James Hougland |
| 09:30 am – 09:45 am | Break |
| 9:45 am – 12:00 pm | Session 3: STRUCTURAL BIOLOGY OF PROTEIN LIPIDATION Session Chair: Bryan Dickinson |
| 09:45 am – 10:05 am | Anirban Banerjee, Bivalent recognition of a fatty acyl CoA by a DHHC enzyme |
| 10:05 am – 10:25 am | Angeline Lyon, Regulation of Phospholipase C epsilon by Small GTPases |
| 10:25 am – 10:40 am | Short Talk 7: George Zheng, Discovery of lysine isobutyrylation as a new histone modification mark |
| 10:40 am – 10:55 am | Live Q&A Panel Discussion |
| 10:55 am - 11:15 am | Laura Burrus, Wnt palmit(e)oylation: A ticket to ride |
| 11:15 am – 11:30 am | Short Talk 8: Jacob Moose, Virtual screening and a continuous acylation assay enables discovery of new GOAT inhibitors |
| 11:30 am – 11:45 am | Short Talk 9: Laurence Abrami, Palmitoylated acyl protein thioesterase LYPLA2 deforms membranes to extract substrate acyl chains |
| 11:45 am – 12:00 pm | Live Q&A Panel Discussion |
| 12:00 pm – 12:15 pm | Break |
| 12:15 pm – 1:00 pm | Career Development Session Jennifer Greaves; Gareth Thomas; Jeff Johnson; Shaun Sanders; Maurine Linder Moderator: Paul Jenkins |
| 1:00 pm – 1:15 pm | Break |
| 1:15 pm – 2:30 pm | Poster Session 2 |
| 2:30 pm – 4:00 pm | Session 4: ENZYMOLOGY OF LIPIDATION Session Chair: Christian Siebold |
| 2:30 pm – 2:50 pm | Marilyn Resh, Fatty Acylation of Hedgehog and Wnt proteins |
| 2:50 pm – 3:10 pm | Jennifer Greaves, Novel acyl protein thioesterases regulate dynamic S-acylation of the SNARE protein SNAP25 |
| 3:10 pm – 3:25 pm | Short Talk 10: Sydney Holme, N-terminal domain of the ABHD17 proteins regulates activity on NRas |
| 3:25 pm – 3:40 pm | Short Talk 11: Alison Ondrus, Small molecule inhibitors of Hedgehog oncoproteins |
| 3:40 pm – 4:00 pm | Live Q&A Panel Discussion |
| 4:00 pm – 4:15 pm | Break |
| 4:15 pm – 5:45 pm | Session 5: NEW FRONTIERS IN PROTEIN LIPIDATION Session Chair: Shernaz Bamji |
| 4:15 pm – 4:35 pm | Davoud Mozhdehi, Genetically encoded lipidation to manipulate the structure, assembly, and phase behavior of proteins |
| 4:35 pm – 4:55 pm | Shafi Kuchay, Lipids and lipid-bound chaperone control compartmental protein targeting via ubiquitin proteasome system |
| 4:55 pm – 5:10 pm | Short Talk 12: Mira Androniciuc, Modulating the Wnt Pathway through Lipid-dependent Interactions |
| 5:10 pm – 5:25 pm | Short Talk 13: John Sanderson, Protein lipidation By uncatalyzed acyl transfer from lipids: Fact or fantasy? |
| 5:25 pm – 5:45 pm | Live Q&A Panel Discussion |
| 5:45 pm – 6:00 pm | Conference Wrap up by Organizers and Conclusion of the Conference |
